Yes! Doing so is very common with a stacked baffle design, like the Mack Brother’s Varminter 3.0 in .308. Having one silencer for all rifle applications doesn’t often impact performance because .308 silencers are longer with additional baffles. Due to its light weight, titanium is one of the most popular materials for application on all sub calibers. Please note that not all .308 silencers work well on a .223. Stack baffle design is typically best for dual application because there is a greater surface area to remove heat from the blast. In recent tests, Dakota Silencer Company found that their own exclusive silencer, the Mack Brothers Varminter 3.0 in .308, was quieter on a .223 than a .223 silencer was.